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Item Do silenciamento nas capas das revistas Veja e IstoÉ: filiações ideológicas em disputa no jogo dos sentidos(UNIVERSIDADE FEDERAL DE ALAGOAS - Ufal, 2025-11-28) Lins, Neilton Farias; Silva, Sóstenes Ericson Vicente da; https://orcid.org/0000-0003-0905-1376; http://lattes.cnpq.br/1308353368649852; Sobrinho, Helson Flavio da Silva; https://orcid.org/0000-0002-8959-3134; http://lattes.cnpq.br/9678771021912570; Silva, Samuel Barbosa; https://orcid.org/0000-0003-3274-3741; http://lattes.cnpq.br/0543187841218105; Neckel, Nádia Régia Maffi; http://lattes.cnpq.br/5132027829423745; Costa, Isaac Itamar de Melo; https://orcid.org/0000-0002-4635-2824; http://lattes.cnpq.br/0452353225402463From the theoretical perspective of Materialist Discourse Analysis, this thesis investigates silence and/or silencing in the discourses conveyed on the covers of the Brazilian weekly magazines VEJA and ISTOÉ, examining the extent to which silencing on these covers produces shifts in the meaning of political or social events, generating effects of highlighting or erasing certain subject-positions. Given the need to understand silencing on the covers of VEJA and ISTOÉ, the analysis addresses how information is silenced, made implicit, or resignified to construct a specific narrative and manipulate the reader’s understanding in the formation of an imaginary that legitimizes practices of capitalist society. The thesis thus questions the process of meaning production in media discourse and its effects. The research aims to analyze how the magazines VEJA and ISTOÉ employ discursive strategies to naturalize discursive functioning for the reader, interpellating readers into pre-given subject-positions that align with dominant ideological positions. The thesis is structured into sections that explore the conditions of discourse production in the magazines, the relationship between silence and discourse on VEJA’s covers, discursive and journalistic events in ISTOÉ’s editorials, the reading of paraphrase and polysemy in ISTOÉ, VEJA’s discourse during the military dictatorship, and the role of magazine covers in capitalist society, with emphasis on the historical basis of neoliberal discourse. The research is grounded in the theoretical conceptions of Michel Pêcheux (1993) and Eni Orlandi (1999), in dialogue with, among others, Courtine (2009), Guilbert and Peñafiel (2019), and Guilbert (2020). The analysis made it possible to examine how silencing, conditions of production, and ideology contribute to the production of meaning and the interpretation of facts by readers. The research findings indicate that silencing is a discursive strategy that helps understand how discursive processes operate through ideology to maintain a certain status quo. Not only that, VEJA and ISTOÉ operate a systematic and ideologically oriented silencing, so that we are not facing accidental silencing, but rather structural and functional silencing serving the neoliberal project, capable of interpellating the middle/upper-class reader to assume ready-made subject-positions, naturalizing the bourgeois order of legitimizing inequalities, criminalizing social movements, delegitimizing progressive governments, etc. In this sense, the thesis demonstrates that the silencing promoted by the respective weeklies does not merely contribute or help to maintain the status quo, it is one of the main mechanisms through which the Brazilian mainstream press actively reproduces the ideological domination of capital in contemporary Brazil.Item Impactos da mineração em micro e pequenos empresários em ambiente de conflitos socioambientais em Maceió/AL(CENTRO UNIVERSITÁRIO DE MACEIÓ - UNIMA | Afya, 2025-09-19) Verde, Marcelo de Barros de Lima; Lima Junior, Walcler Mendes de; http://lattes.cnpq.br/6938727316741941; Rodrigues, Diego Freitas; http://lattes.cnpq.br/4648723371446148; Almeida, Natállya Levino de; http://lattes.cnpq.br/2495024004949828; Fonseca, Débora de Barros Cavalcanti; http://lattes.cnpq.br/5479297370165991; Junkes, Janaína Accordi; http://lattes.cnpq.br/7777461824456062; Miyazawa, Ana Paula; http://lattes.cnpq.br/6462133462005479In Alagoas, mining activities have been taking place in the city of Maceió since the 1970s to extract rock salt, a type of sodium chloride used in the manufacture of caustic soda and PVC. In February 2018, after heavy rains and an earthquake, several cracks appeared in streets and properties in the Pinheiro neighborhood. A year later, the same phenomenon was also recorded in the neighborhoods of Mutange, Bebedouro, Bom Parto and Farol, resulting in the expulsion of approximately 60,000 people from the five neighborhoods affected by the overexploitation of rock salt and the closure of more than 6,000 companies. The objective of the research was to analyze the impacts on the businesses of micro and small entrepreneurs affected by the mining disaster in Maceió, Alagoas. In order to analyze the impact of such a disaster on entrepreneurs/traders, the study uses a mixed approach, of the explanatory sequential type. The first phase, quantitative, was characterized as a cross-sectional study, while the second phase was qualitative, exploratory and descriptive in nature. The environmental disaster caused by rock salt mining contributed to losses for micro and small businesses in the affected neighborhoods. In addition to the economic impact, the disaster caused by the subsidence of the soil caused by the Braskem mining company also caused damage to the mental health of micro and small business owners in the region, according to the participants in the survey, which took place between May 2023 and December 2024. Regarding the value of the PCF from the Braskem mining company for business owners: 3% thought the amount of financial compensation paid was fair, while 34% said it was not. The decrease in revenue and financial difficulties led to the closure of numerous companies and the loss of jobs. Dissatisfaction with the social rent paid by the Braskem mining company and the compromised mental health were reported by the majority of business owners. Keywords: Mining, Micro and small businesses, Entrepreneurs/Traders, Maceió.Item Predição in silico de candidato vacinal multi-epítopo antigênico tumoral para o antígeno testicular de câncer - TFDP3(UNIVERSIDADE FEDERAL DE ALAGOAS - Ufal, 2024-02-19) Omena Neta, Genilda Castro de; Marques, Carolinne de Sales; https://orcid.org/0000-0003-2902-0657; http://lattes.cnpq.br/2138096354768853; Fraga, Carlos Alberto de Carvalho; https://orcid.org/0000-0002-9564-9595; http://lattes.cnpq.br/1658892101106938; Koike, Bruna Del Vechio; https://orcid.org/0000-0001-9745-3513; http://lattes.cnpq.br/6190033586443279; Baggio, Jussara Almeida de Oliveira; https://orcid.org/0000-0003-2508-1364; http://lattes.cnpq.br/8921152292383528; Rodrigues, Amanda Karine Barros Ferreira; https://orcid.org/0000-0002-6668-2820; http://lattes.cnpq.br/8927116542464621; Gomes, Francis Soares; http://lattes.cnpq.br/8626107472806227The increase in cancer incidence and mortality worldwide has demonstrated the need for investment in more effective anti-tumor therapies. Given the complexity of the mechanisms that lead to resistance to anti-tumor treatments, target therapies are promising approaches. Cancer testicular antigens (CTAs) are therapeutic targets with potential to be explored, as they are not expressed in normal cells and are expressed in tumor cells, as is the case with TFDP3, expressed in triple negative breast cancer, prostate cancer, childhood T-cell lymphoblastic leukemia and hepatocellular carcinoma. The objective proposed in this work is the in silico prediction of a multi-epitope tumor antigen vaccine candidate from TFDP3. The epitopes were screened using immunoinformatics tools that identified the antigenic epitopes that interacted with B lymphocytes, CD4+ T lymphocytes and CD8+ T lymphocytes. The population coverage of the epitopes on CD4+ T lymphocytes and CD8+ T lymphocytes was then assessed. From the epitopes of B lymphocytes, CD4+ T lymphocytes and CD8+ T lymphocytes, 3 epitopes from each were selected to make up the multi-epitope vaccine determined by antigenicity, allergenicity, toxicity, IFN-γ induction and population coverage. In addition to the epitopes, the vaccine was made up of an adjuvant and ligands that ensured certain properties of the epitopes, their processing in MHC class I biosynthesis and post-translational modifications. The vaccine's homology with other proteins was assessed using the NCBI BLASTp server. The physicochemical parameters, antigenicity, allergenicity and toxicity were then evaluated. The secondary structure and tertiary structure were determined using servers that use neural networks, as well as the quality parameters associated with the structure. In the tertiary structure, the linear and discontinuous epitopes of B lymphocytes were determined using the IEDB server. From there, the interaction by molecular docking with Toll-like receptors and molecular dynamics were evaluated to assess the stability of the multi-epitope vaccine in a biological system. Finally, the in silico assessment of the possibility of cloning the multi-epitope vaccine and its immune response after 1 and 3 successive administrations was also evaluated. Epitopes that interact with antigenic, non-allergenic and non-toxic B lymphocytes, CD4+ T lymphocytes and CD8+ T lymphocytes were identified. With regard to CD4+ T lymphocytes, 4 epitopes, as well as being antigenic, non-llergenic and non-toxic, are possible inducers of IFN-γ. In the population coverage, the MHC class I and MHC class II epitopes had 93.55% coverage worldwide. The multi-epitope vaccine has biologically favorable physicochemical parameters, low homology with human proteins, secondary and tertiary conformation compatible with native protein structures. It also has interactions with TLR-2 and TLR-3, with TLR-3 being the interaction that in a biological system guarantees the greatest stability of the multi-epitope vaccine. In addition, in silico analyses have shown that the multi-epitope vaccine can be cloned and develop a more robust and prolonged immune response when submitted to 3 administrations. Therefore, the multi-epitope vaccine designed from the testicular cancer antigen TFDP3 showed in silico several promising biological properties and responses so that in vitro and in vivo studies can be invested and the future application of this vaccine in the treatment of cancer types that express this CTA.